Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 16/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28046442 | 1.00 | ABL1 (0.70) | ABL1MAPK14LCKKDRCSF1R | |
| SCHEMBL28046460 | 0.93 | ABL1 (0.67) | ABL1MAPK14LCKKDRCSF1R | |
| SCHEMBL28046474 | 0.89 | ABL1 (0.68) | ABL1MAPK14LCKKDRCSF1R | |
| SCHEMBL14244939 | 0.82 | ABL1 (1.00) | ABL1 | |
| SCHEMBL15402851 | 0.82 | ABL1 (1.00) | ABL1 | |
| SCHEMBL10288057 | 0.82 | ABL1 (1.00) | ABL1 | |
| SCHEMBL28046496 | 0.82 | ABL1 (0.53) | ABL1MAPK14LCKKDRCSF1R | |
| SCHEMBL28046472 | 0.81 | ABL1 (0.62) | ABL1MAPK14 | |
| SCHEMBL28046448 | 0.80 | ABL1 (0.66) | ABL1 | |
| SCHEMBL28046485 | 0.80 | ABL1 (0.60) | ABL1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103261167-B | 6 of replacement, 6-condenses nitrogen-containing heterocycle compound and uses thereof | HOFFMAN-LA ROCHE LTD. (CH) | 2016-05-04 | — | — | CN | claimed |