Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.47 |
| ▸ | TP53 | P04637 | 6/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL280158 | 0.90 | MAPT (0.41) | MAPTTP53THRBLMNAPTPN1 | |
| SCHEMBL10207171 | 0.86 | MAPT (0.49) | MAPTTP53THRBLMNAPTPN1 | |
| SCHEMBL280031 | 0.83 | PTPN1 (0.40) | MAPTTP53THRBLMNAPTPN1 | |
| SCHEMBL278642 | 0.83 | MAPT (0.37) | MAPTTP53THRBLMNAPTPN1 | |
| SCHEMBL10207172 | 0.82 | PPARD (0.52) | MAPTTP53LMNAPTPN1 | |
| SCHEMBL279546 | 0.82 | MAPT (0.46) | MAPTTP53THRBLMNA | |
| SCHEMBL280320 | 0.82 | LMNA (0.39) | MAPTTP53THRBLMNAPTPN1 | |
| SCHEMBL279879 | 0.81 | LMNA (0.41) | MAPTTP53THRBLMNAPTPN1 | |
| SCHEMBL280312 | 0.80 | MAPT (0.47) | MAPTTP53THRBLMNA | |
| SCHEMBL3371249 | 0.80 | MAPT (0.48) | MAPTTP53THRBLMNAPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134010-B2 | 4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenylamine; N-{4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenyl}-acetamide; or4-Methyl-5-(2-nitrooxy-ethyl)-2-(4-nitro-phenyl)-thiazole; cardiovascular, gastrointestinal, inflammatory, respiratory disease | RENOPHARM LTD. (IL) | 2012-03-13 | — | — | US | disclosed |
| US-7968575-B2 | Nitric oxide donors and uses thereof | RENOPHARM LTD. (IL) | 2011-06-28 | — | — | US | disclosed |
| US-7579477-B2 | Thiazole-based nitric oxide donors having alkyl substituent(s) and uses thereof | RENOPHARM LTD. (IL) | 2009-08-25 | — | — | US | disclosed |
| US-7498445-B2 | Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof | RENOPHARM LTD. (IL) | 2009-03-03 | — | — | US | disclosed |
| US-7368577-B2 | Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof | RENOPHARM LTD. (IL) | 2008-05-06 | — | — | US | disclosed |
| US-7332513-B2 | Thiazole-based nitric oxide donors having acyl substituent(s) and uses thereof | RENOPHARM LTD. (IL) | 2008-02-19 | — | — | US | disclosed |