Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 15/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 15/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 15/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2803902 | 0.95 | CYP2C19 (0.34) | ALDH1A1LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2802823 | 0.90 | SLC6A4 (0.35) | LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2805222 | 0.90 | CHEK1 (0.32) | LMNASLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL2803313 | 0.90 | SLC6A2 (0.31) | SLC6A2SLC6A4SLC6A3CYP2D6CYP2C19 | |
| SCHEMBL16351170 | 0.89 | MEN1 (0.37) | ALDH1A1LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2802547 | 0.89 | RAB9A (0.35) | ALDH1A1LMNARECQLSLC6A2SLC6A4 | |
| SCHEMBL2803262 | 0.88 | CHEK1 (0.36) | LMNARECQLCYP2C19CYP3A4 | |
| SCHEMBL2805043 | 0.88 | CHRM3 (0.37) | SLC6A2SLC6A4SLC6A3CYP2D6CYP2C19 | |
| SCHEMBL2805897 | 0.88 | FFAR1 (0.34) | SLC6A2SLC6A4SLC6A3CYP2D6CYP2C19 | |
| SCHEMBL2803852 | 0.88 | HRH3 (0.45) | ALDH1A1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379506-B1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE INC (US) | 2015-09-02 | — | — | EP | disclosed |
| EP-2379506-B1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE INC (US) | 2015-09-02 | — | — | EP | disclosed |
| US-8357694-B2 | Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds | ARQULE, INC. (US) | 2013-01-22 | — | — | US | disclosed |
| US-8357694-B2 | Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds | ARQULE, INC. (US) | 2013-01-22 | — | — | US | disclosed |
| US-20100239525-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| WO-2010078421-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100239525-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | NQO1, DPYD, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | ALDH1A1 510/4885LMNA 1658/4885RECQL 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.