Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | RORC | P51449 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18787549 | 0.93 | KCNH2 (0.47) | KCNH2RORCALDH1A1MAPTMGLL | |
| SCHEMBL17295599 | 0.93 | KCNH2 (0.47) | KCNH2RORCALDH1A1MAPTMGLL | |
| SCHEMBL15778101 | 0.88 | KCNH2 (0.64) | KCNH2RORC | |
| SCHEMBL15778102 | 0.88 | KCNH2 (0.64) | KCNH2RORC | |
| SCHEMBL15777777 | 0.87 | ALDH1A1 (0.47) | KCNH2RORCALDH1A1MAPTLMNA | |
| SCHEMBL17182378 | 0.87 | ALDH1A1 (0.47) | KCNH2RORCALDH1A1MAPTLMNA | |
| SCHEMBL19381059 | 0.86 | KCNH2 (0.47) | KCNH2RORCALDH1A1MAPTCCR1 | |
| SCHEMBL17182361 | 0.85 | KCNH2 (0.46) | KCNH2RORCALDH1A1MAPTMGLL | |
| SCHEMBL15778171 | 0.85 | KCNH2 (0.46) | KCNH2RORCALDH1A1MAPTMGLL | |
| SCHEMBL18695721 | 0.85 | KCNH2 (0.52) | KCNH2RORCALDH1A1MAPTTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105121430-A | Modulators of the retinoid-related orphan receptor gamma (ror-gamma) for use in the treatment of autoimmune and inflammatory diseases | GLAXO GROUP LTD | 2015-12-02 | — | — | CN | disclosed |