Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.51 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | PARG | Q86W56 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3640665 | 0.94 | MAPT (0.53) | MAPTRAB9ANPC1HIF1AGPR35 | |
| SCHEMBL10743403 | 0.88 | GPR35 (0.64) | MAPTRAB9ANPC1HIF1AGPR35 | |
| SCHEMBL28047029 | 0.84 | HIF1A (0.51) | MAPTRAB9ANPC1HIF1AL3MBTL1 | |
| SCHEMBL3646419 | 0.81 | HIF1A (0.51) | MAPTRAB9ANPC1HIF1AL3MBTL1 | |
| SCHEMBL24470709 | 0.81 | KMT2A (0.58) | MAPTNPC1HIF1AL3MBTL1KDM4E | |
| SCHEMBL29713164 | 0.81 | KMT2A (0.58) | MAPTNPC1HIF1AL3MBTL1KDM4E | |
| SCHEMBL11698424 | 0.80 | KDM4E (0.47) | MAPTRAB9ANPC1HIF1AL3MBTL1 | |
| SCHEMBL3648813 | 0.79 | BRAF (0.44) | MAPTRAB9ANPC1HIF1AL3MBTL1 | |
| SCHEMBL20893367 | 0.79 | MCL1 (0.67) | MAPTRAB9ANPC1HIF1AL3MBTL1 | |
| SCHEMBL9378819 | 0.79 | KDM4E (0.69) | MAPTRAB9AHIF1AUSP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105164112-A | Amide compound and preparation method, pharmaceutical composition and application thereof | SHANGHAI INST MATERIA MEDICA | 2015-12-16 | — | — | CN | disclosed |