Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 15/20 | 0.36 |
| ▸ | CA2 | P00918 | 15/20 | 0.36 |
| ▸ | MMP1 | P03956 | 15/20 | 0.36 |
| ▸ | MMP2 | P08253 | 15/20 | 0.36 |
| ▸ | MMP9 | P14780 | 15/20 | 0.36 |
| ▸ | MMP8 | P22894 | 15/20 | 0.36 |
| ▸ | MMP13 | P45452 | 15/20 | 0.36 |
| ▸ | LOX | P28300 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15880654 | 0.67 | CA2 (0.54) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL15881368 | 0.67 | CA2 (0.41) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL15880569 | 0.60 | MAPT (0.46) | POLB | |
| SCHEMBL15881394 | 0.60 | HPGD (0.48) | CA1CA2POLB | |
| SCHEMBL5357837 | 0.60 | CA1 (0.35) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL15880524 | 0.60 | CDK5 (0.40) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL3126304 | 0.58 | LOX (0.51) | LOXLOXL2 | |
| SCHEMBL12190292 | 0.57 | CA1 (0.70) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL8233017 | 0.57 | CA1 (0.50) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL15880546 | 0.56 | CA2 (0.52) | CA1CA2MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105142627-A | Pharmaceutical compositions comprising nitroxyl donors | CARDIOXYL PHARMACEUTICALS INC | 2015-12-09 | — | — | CN | disclosed |