SCHEMBL28047480

SCHEMBL28047480

COc1cccc(Cl)c1C(F)F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.41
CA2 P00918 3/20 0.41
CA12 O43570 2/20 0.41
CA7 P43166 2/20 0.41
CA9 Q16790 2/20 0.41
CA14 Q9ULX7 2/20 0.41
CA4 P22748 1/20 0.41
L3MBTL1 Q9Y468 4/20 0.40
ACHE P22303 2/20 0.39
NQO2 P16083 1/20 0.39
MAPT P10636 4/20 0.38
HPGD P15428 3/20 0.38
ALDH1A1 P00352 2/20 0.38
KDM4E B2RXH2 2/20 0.38
CYP3A4 P08684 2/20 0.38
LMNA P02545 1/20 0.38
TP53 P04637 1/20 0.38
ALOX15 P16050 1/20 0.38
ALOX12 P18054 1/20 0.38
MAPK1 P28482 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12985782 0.82 KDM4E (0.46) CA1CA2CA12CA7CA9
SCHEMBL2424023 0.78 CA1 (0.41) CA1CA2CA12CA7CA9
SCHEMBL16118268 0.78 CA1 (0.41) CA1CA2CA12CA7CA9
SCHEMBL14955912 0.78 CYP1A2 (0.43) ALDH1A1CYP3A4LMNATDP1CYP1A2
SCHEMBL31446707 0.77 AKR1C3 (0.52) CA1CA2CA12CA7CA9
SCHEMBL28982986 0.76 L3MBTL1 (0.35) L3MBTL1MAPTHPGDALDH1A1KDM4E
SCHEMBL13939459 0.75 CA1 (0.55) CA1CA2CA12CA7CA9
SCHEMBL28773769 0.74 L3MBTL1 (0.36) CA1CA2CA12CA7CA9
SCHEMBL1728265 0.72 CA12 (0.46) CA1CA2CA12CA7CA9
SCHEMBL687479 0.72 CA1 (0.46) CA1CA2CA12CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105208859-A Novel 4-aminopyridine and 6-aminopyrimidine carboxylates as herbicides DOW AGROSCIENCES LLC 2015-12-30 CN disclosed