Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GRM8 | O00222 | 1/20 | 0.32 |
| ▸ | GRM6 | O15303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1840371 | 0.81 | EPHX2 (0.40) | APLNREPHX2LMNABLMFFAR3 | |
| SCHEMBL4443561 | 0.81 | APLNR (0.56) | APLNREPHX2LMNABLMFFAR3 | |
| SCHEMBL6628367 | 0.79 | APLNR (0.37) | APLNREPHX2LMNABLMFFAR3 | |
| SCHEMBL2232346 | 0.79 | SMN1; SMN2 (0.43) | APLNREPHX2LMNABLMGRM2 | |
| SCHEMBL20854992 | 0.77 | EPHX2 (0.38) | APLNREPHX2LMNABLMTSHR | |
| SCHEMBL19913354 | 0.75 | APLNR (0.34) | APLNREPHX2LMNABLM | |
| SCHEMBL4915472 | 0.75 | TP53 (0.46) | EPHX2CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3631699 | 0.75 | APLNR (0.34) | APLNREPHX2LMNABLMTSHR | |
| SCHEMBL17574160 | 0.74 | APLNR (0.33) | APLNREPHX2LMNABLM | |
| SCHEMBL23263231 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104053661-B | The thienopyrimidines inhibitor of atypical protein kinase C | 癌症研究技术有限公司 | 2018-06-19 | — | — | CN | disclosed |
| CN-104024258-B | Pyrrolopyrazine kinase inhibitors | 霍夫曼-拉罗奇有限公司 | 2017-02-15 | — | — | CN | disclosed |
| CN-103443099-B | Regulate composition and the method for FXR | NOVARTIS AG (CH) | 2016-03-23 | — | — | CN | disclosed |
| CN-101686680-B | Bicyclic heteroaryl compounds as P2X7 modulators and uses thereof | Ivotec America Inc. (US) | 2015-12-09 | — | — | CN | disclosed |