Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | MC3R | P41968 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.41 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isocaffiene SCHEMBL515995 | 0.81 | LMNA (0.57) | LMNAALDH1A1MAPTPOLBADORA2B | |
| SCHEMBL1962417 | 0.80 | LMNA (0.69) | LMNAALDH1A1MAPTPOLBADORA2B | |
| SCHEMBL8136340 | 0.78 | LMNA (0.54) | LMNAALDH1A1MAPTPOLBADORA2B | |
| SCHEMBL3272841 | 0.78 | LMNA (0.54) | LMNAALDH1A1MAPTPOLBADORA2B | |
| SCHEMBL8679546 | 0.76 | LMNA (0.64) | LMNAALDH1A1MAPTPOLBADORA2B | |
| SCHEMBL23974579 | 0.74 | LMNA (0.50) | LMNAALDH1A1MAPTPOLBADORA2B | |
| SCHEMBL19953694 | 0.74 | LMNA (0.66) | LMNAALDH1A1MAPTPOLBADORA2B | |
| SCHEMBL23974577 | 0.74 | LMNA (0.54) | LMNAALDH1A1MAPTPOLBADORA2B | |
| SCHEMBL17682185 | 0.74 | LMNA (0.50) | LMNAALDH1A1MAPTPOLBADORA2B | |
| SCHEMBL19601295 | 0.73 | LMNA (0.49) | LMNAALDH1A1MAPTPOLBADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107954991-A | Substituted indoles -5- amphyls and their treatment use | 南特生物科学公司 | 2018-04-24 | — | — | CN | disclosed |
| CN-105377261-B | Substituted indol-5-ol derivatives and their therapeutic use | 南特生物科学公司 | 2017-12-15 | — | — | CN | disclosed |
| CN-105377261-A | Substituted indol-5-ol derivatives and their therapeutic use | NANTBIO INC | 2016-03-02 | — | — | CN | disclosed |