Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL96547 | 0.81 | LMNA (0.57) | CYP3A4LMNAKDM4ENPC1ALDH1A1 | |
| SCHEMBL13981821 | 0.78 | HPGD (0.62) | AAK1CYP3A4LMNAKDM4ENPC1 | |
| SCHEMBL470844 | 0.75 | AAK1 (0.47) | AAK1CYP3A4LMNAKDM4ENPC1 | |
| SCHEMBL30483430 | 0.75 | LMNA (0.64) | AAK1CYP3A4LMNAKDM4ENPC1 | |
| SCHEMBL15217049 | 0.75 | AAK1 (0.47) | AAK1CYP3A4LMNAKDM4ENPC1 | |
| SCHEMBL8607765 | 0.75 | AAK1 (0.56) | AAK1CYP3A4LMNAKDM4ENPC1 | |
| SCHEMBL10256230 | 0.74 | APP (0.41) | NPC1TSHRRAB9ACYP2D6SMN1; SMN2 | |
| SCHEMBL17132270 | 0.73 | CYP3A4 (0.44) | AAK1CYP3A4LMNAKDM4ENPC1 | |
| SCHEMBL28609646 | 0.71 | TP53 (0.56) | CYP3A4LMNAALDH1A1TSHRHSD17B10 | |
| SCHEMBL14016311 | 0.71 | TP53 (0.56) | CYP3A4LMNAALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105189515-A | Furopyridines as bromodomain inhibitors | GLAXOSMITHKLINE IP NO 2 LTD | 2015-12-23 | — | — | CN | disclosed |