⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23539861 | 1.00 | — | — | |
| SCHEMBL23540957 | 1.00 | — | — | |
| SCHEMBL1970500 | 0.81 | — | — | |
| SCHEMBL360480 | 0.81 | — | — | |
| SCHEMBL13448335 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL20746533 | 0.78 | — | — | |
| SCHEMBL4544771 | 0.77 | — | — | |
| SCHEMBL27782220 | 0.75 | TSHR (0.41) | — | |
| SCHEMBL19257464 | 0.75 | TSHR (0.41) | — | |
| SCHEMBL5972281 | 0.75 | LMNA (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118076612-A | Sulfur-containing heteroaromatic tricyclic KRAS inhibitors | 医睿世康药业研发公司 | 2024-05-24 | — | — | CN | disclosed |
| EP-4217071-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | Erasca, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-4076667-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | Erasca, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2022066805-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2022-03-31 | — | — | WO | disclosed |
| CN-105189743-A | Method for producing recombinant protein of interest | SANDOZ AG | 2015-12-23 | — | — | CN | disclosed |