Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2034798 | 0.89 | CHEK1 (0.47) | HRH4CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL2403564 | 0.88 | HRH4 (0.50) | HRH4HTR2C | |
| SCHEMBL28063327 | 0.79 | HRH3 (0.42) | HRH4HTR3ACHEK1CCNA2CDK2 | |
| SCHEMBL2637316 | 0.77 | TLR9 (0.39) | HTR3AMPOHTR2AHTR2C | |
| SCHEMBL20577260 | 0.77 | TLR9 (0.39) | HTR3AMPOHTR2AHTR2C | |
| SCHEMBL16789827 | 0.77 | PDE10A (0.42) | HRH4 | |
| SCHEMBL14240499 | 0.77 | HRH4 (0.44) | HRH4HTR2C | |
| SCHEMBL28383379 | 0.75 | HRH4 (0.33) | HRH4 | |
| SCHEMBL28460425 | 0.73 | HRH4 (0.40) | HRH4HTR3AMPOCHEK1CCNA2 | |
| SCHEMBL2176046 | 0.71 | BACE1 (0.44) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105367503-A | HETEROARYL COMPOUNDS AND USES THEREOF | AVILA THERAPEUTICS INC | 2016-03-02 | — | — | CN | disclosed |
| CN-101902911-B | Heteroaryl compounds and uses thereof | AVILA THERAPEUTICS, INC. (US) | 2015-12-16 | — | — | CN | disclosed |