Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | MIF | P14174 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3361308 | 1.00 | MEN1 (0.37) | MEN1MAPK1KMT2ANFKB1NFKB2 | |
| SCHEMBL3649894 | 0.81 | MEN1 (0.38) | MEN1MAPK1KMT2ANFKB1NFKB2 | |
| SCHEMBL1636481 | 0.81 | MEN1 (0.38) | MEN1MAPK1KMT2ANFKB1NFKB2 | |
| SCHEMBL3694232 | 0.81 | MEN1 (0.38) | MEN1MAPK1KMT2ANFKB1NFKB2 | |
| SCHEMBL4383932 | 0.77 | KMT2A (0.37) | MEN1MAPK1KMT2ANFKB1NFKB2 | |
| SCHEMBL13330958 | 0.77 | MEN1 (0.38) | MEN1MAPK1KMT2ANFKB1NFKB2 | |
| SCHEMBL13302346 | 0.77 | MEN1 (0.38) | MEN1MAPK1KMT2ANFKB1NFKB2 | |
| SCHEMBL13302345 | 0.77 | MEN1 (0.38) | MEN1MAPK1KMT2ANFKB1NFKB2 | |
| SCHEMBL8372247 | 0.77 | MEN1 (0.38) | MEN1MAPK1KMT2ANFKB1NFKB2 | |
| SCHEMBL2630659 | 0.77 | MEN1 (0.38) | MEN1MAPK1KMT2ANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103936819-B | Hepatitis c virus inhibitors | 百时美施贵宝公司 | 2016-11-16 | — | — | CN | disclosed |
| CN-105254637-A | PYRIMIDINE SUBSTITUTED MACROCYCLIC INHIBITORS | JANSSEN R & D IRELAND | 2016-01-20 | — | — | CN | disclosed |