SCHEMBL2805039

SCHEMBL2805039

c1ccc(-c2nnc(-c3ccc(N(c4ccccc4)c4ccc(-c5ccc6c(c5)c5ccccc5n6-c5ccccc5)cc4)cc3)o2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.42
ATM Q13315 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
NPC1 O15118 11/20 0.41
RAB9A P51151 11/20 0.41
SMN1; SMN2 Q16637 7/20 0.41
HPGD P15428 5/20 0.41
ALDH1A1 P00352 5/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
MAPT P10636 2/20 0.40
GLA P06280 1/20 0.40
ALOX15 P16050 1/20 0.40
HSD17B10 Q99714 1/20 0.40
TSPO P30536 1/20 0.39
POLB P06746 2/20 0.38
NFKB1 P19838 1/20 0.38
NFKB2 Q00653 1/20 0.38
RELA Q04206 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11987952 1.00 KDM4E (0.42) KDM4EATML3MBTL1NPC1RAB9A
SCHEMBL11987949 0.99 KDM4E (0.43) KDM4EATML3MBTL1NPC1RAB9A
SCHEMBL11987964 0.98 NPC1 (0.41) KDM4EATML3MBTL1NPC1RAB9A
SCHEMBL11987957 0.97 KDM4E (0.39) KDM4EATML3MBTL1NPC1RAB9A
SCHEMBL11987950 0.97 KDM4E (0.39) KDM4EATML3MBTL1NPC1RAB9A
SCHEMBL11987966 0.96 NPC1 (0.42) KDM4ENPC1RAB9ASMN1; SMN2HPGD
SCHEMBL11987971 0.96 NPC1 (0.42) KDM4ENPC1RAB9ASMN1; SMN2HPGD
SCHEMBL14466534 0.95 KDM4E (0.42) KDM4EATML3MBTL1NPC1RAB9A
SCHEMBL14465691 0.95 KDM4E (0.42) KDM4EATML3MBTL1NPC1RAB9A
SCHEMBL14466524 0.94 KDM4E (0.39) KDM4EATML3MBTL1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8530658-B2 Carbazole derivative with heteroaromatic ring, and light-emitting element, light-emitting device, and electronic device using carbazole derivative with heteroaromatic ring SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2013-09-10 US disclosed
US-8530658-B2 Carbazole derivative with heteroaromatic ring, and light-emitting element, light-emitting device, and electronic device using carbazole derivative with heteroaromatic ring SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2013-09-10 US disclosed
US-8530658-B2 Carbazole derivative with heteroaromatic ring, and light-emitting element, light-emitting device, and electronic device using carbazole derivative with heteroaromatic ring SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2013-09-10 US disclosed
US-20120302751-A1 Carbazole Derivative with Heteroaromatic Ring, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using Carbazole Derivative with Heteroaromatic Ring SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-11-29 US disclosed
US-20120302751-A1 Carbazole Derivative with Heteroaromatic Ring, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using Carbazole Derivative with Heteroaromatic Ring SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-11-29 US disclosed
US-20120302751-A1 Carbazole Derivative with Heteroaromatic Ring, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using Carbazole Derivative with Heteroaromatic Ring SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-11-29 US disclosed
US-8247575-B2 Carbazole derivative with heteroaromatic ring, and light-emitting element, light-emitting device, and electronic device using carbazole derivative with heteroaromatic ring SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2012-08-21 US disclosed
US-8247575-B2 Carbazole derivative with heteroaromatic ring, and light-emitting element, light-emitting device, and electronic device using carbazole derivative with heteroaromatic ring SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2012-08-21 US disclosed
US-8247575-B2 Carbazole derivative with heteroaromatic ring, and light-emitting element, light-emitting device, and electronic device using carbazole derivative with heteroaromatic ring SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2012-08-21 US disclosed
US-20100237339-A1 Carbazole Derivative with Heteroaromatic Ring, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using Carbazole Derivative with Heteroaromatic Ring SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2010-09-23 US disclosed
US-20100237339-A1 Carbazole Derivative with Heteroaromatic Ring, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using Carbazole Derivative with Heteroaromatic Ring SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2010-09-23 US disclosed
US-20100237339-A1 Carbazole Derivative with Heteroaromatic Ring, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using Carbazole Derivative with Heteroaromatic Ring SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2010-09-23 US disclosed
US-20100237773-A1 Carbazole Derivative with Heteroaromatic Ring, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using Carbazole Derivative with Heteroaromatic Ring SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2010-09-23 US disclosed
US-20100237773-A1 Carbazole Derivative with Heteroaromatic Ring, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using Carbazole Derivative with Heteroaromatic Ring SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2010-09-23 US disclosed
US-20100237773-A1 Carbazole Derivative with Heteroaromatic Ring, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using Carbazole Derivative with Heteroaromatic Ring SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2010-09-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100237773-A1 Carbazole Derivative with Heteroaromatic Ring, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using Carbazole Derivative with Heteroaromatic Ring SLC43A3, CRY1, VDAC3 KDM4E 3212/4885ATM 3672/4885L3MBTL1 842/4885
US-20120302751-A1 Carbazole Derivative with Heteroaromatic Ring, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using Carbazole Derivative with Heteroaromatic Ring SLC43A3, CRY1, VDAC3 KDM4E 3212/4885ATM 3672/4885L3MBTL1 842/4885
US-20100237339-A1 Carbazole Derivative with Heteroaromatic Ring, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using Carbazole Derivative with Heteroaromatic Ring SLC43A3, CRY1, VDAC3 KDM4E 3212/4885ATM 3672/4885L3MBTL1 842/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.