Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 10/20 | 0.86 |
| ▸ | TNIK | Q9UKE5 | 9/20 | 0.64 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.59 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.58 |
| ▸ | IKBKB | O14920 | 1/20 | 0.58 |
| ▸ | CHUK | O15111 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | INSR | P06213 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL723895 | 0.93 | MAP3K11 (1.00) | MAP3K11TNIKMAP4K1MAP3K9IKBKB | |
| SCHEMBL722116 | 0.93 | MAP3K11 (1.00) | MAP3K11TNIKMAP4K1MAP3K9IKBKB | |
| SCHEMBL28050358 | 0.91 | MAP3K11 (0.72) | MAP3K11TNIKMAP3K9ABL1INSR | |
| SCHEMBL721840 | 0.91 | MAP3K11 (0.83) | MAP3K11TNIKMAP4K1MAP3K9IKBKB | |
| SCHEMBL28050406 | 0.90 | TNIK (0.73) | MAP3K11TNIKMAP4K1MAP3K9IKBKB | |
| SCHEMBL28033172 | 0.87 | TNIK (0.70) | MAP3K11TNIKMAP4K1MAP3K9IKBKB | |
| SCHEMBL720661 | 0.87 | MAP3K11 (0.79) | MAP3K11TNIKMAP4K1MAP3K9IKBKB | |
| SCHEMBL28032700 | 0.86 | MAP3K11 (0.65) | MAP3K11TNIKMAP4K1MAP3K9IKBKB | |
| SCHEMBL28822401 | 0.85 | MAP3K11 (0.64) | MAP3K11TNIKMAP4K1MAP3K9IKBKB | |
| SCHEMBL15154839 | 0.84 | MAP3K11 (0.85) | MAP3K11TNIKMAP4K1MAP3K9IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103153994-B | Bicyclic heteroaryl kinase inhibitor and using method | UNIVERSITY OF ROCHESTER (US) | 2016-02-10 | — | — | CN | disclosed |