Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | PIN1 | Q13526 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.44 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27894560 | 0.98 | NPC1 (0.52) | NPC1RAB9APIN1POLBL3MBTL1 | |
| SCHEMBL11238251 | 0.83 | NPC1 (0.49) | NPC1RAB9APIN1POLBL3MBTL1 | |
| SCHEMBL4013450 | 0.83 | NPC1 (0.49) | NPC1RAB9APIN1POLBL3MBTL1 | |
| SCHEMBL15754676 | 0.81 | NPC1 (0.47) | NPC1RAB9APIN1POLBL3MBTL1 | |
| SCHEMBL24380269 | 0.79 | L3MBTL1 (0.47) | NPC1RAB9APIN1POLBL3MBTL1 | |
| SCHEMBL24380353 | 0.79 | POLB (0.47) | NPC1RAB9APIN1POLBL3MBTL1 | |
| SCHEMBL384952 | 0.76 | NPC1 (0.61) | NPC1RAB9APIN1POLBL3MBTL1 | |
| SCHEMBL18662554 | 0.76 | PRSS1 (0.45) | NPC1RAB9APIN1POLBL3MBTL1 | |
| SCHEMBL19611826 | 0.75 | BTK (0.47) | NPC1RAB9APIN1POLBL3MBTL1 | |
| SCHEMBL2177064 | 0.75 | MAPT (0.49) | NPC1RAB9APOLBL3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105189484-A | Cxcr7 antagonists | CHEMOCENTRYX INC | 2015-12-23 | — | — | CN | disclosed |