Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 5/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28269737 | 0.87 | MAOB (0.40) | MTNR1AMTNR1BPDE10AMAPTSMN1; SMN2 | |
| SCHEMBL27987661 | 0.85 | TEC (0.45) | MTNR1AMTNR1BTXNRD1PDE10ALMNA | |
| SCHEMBL30081479 | 0.82 | BACE1 (0.53) | MTNR1AMTNR1BPDE10AMAPTBACE1 | |
| SCHEMBL19808389 | 0.79 | CYP1A2 (0.46) | MTNR1AMTNR1BPDE10ALMNAMAPT | |
| SCHEMBL28269735 | 0.78 | PDE10A (0.41) | MTNR1AMTNR1BPDE10ASMN1; SMN2HDAC3 | |
| SCHEMBL21458325 | 0.78 | MTNR1A (0.47) | MTNR1AMTNR1BPDE10AAPPHDAC3 | |
| SCHEMBL31731406 | 0.78 | MTNR1A (0.47) | MTNR1AMTNR1BPDE10AAPPHDAC3 | |
| SCHEMBL28271357 | 0.75 | PDE10A (0.45) | PDE10A | |
| SCHEMBL11830895 | 0.75 | MTNR1A (0.45) | MTNR1AMTNR1BPDE10ALMNAPOLB | |
| SCHEMBL11832008 | 0.75 | MTNR1A (0.51) | MTNR1AMTNR1BPDE10ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105829294-A | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | 詹森药业有限公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-105636952-A | Secondary alcohol quinolinyl modulators of roryt | JANSSEN PHARMACEUTICA NV | 2016-06-01 | — | — | CN | disclosed |
| CN-105209453-A | Methylene linked quinolinyl modulators of ROR-gamma-T | JANSSEN PHARMACEUTICA NV | 2015-12-30 | — | — | CN | disclosed |