Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 2/20 | 0.61 |
| ▸ | PDE5A | O76074 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SPR | P35270 | 2/20 | 0.49 |
| ▸ | PTGES | O14684 | 4/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13789347 | 0.80 | SMN1; SMN2 (0.51) | GUSBPDE5AMAPTMEN1KMT2A | |
| SCHEMBL5482863 | 0.80 | PDE5A (0.72) | GUSBPDE5AMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL29398836 | 0.80 | KDM4E (0.57) | GUSBPDE5AMAPTHTTRAB9A | |
| SCHEMBL14343548 | 0.77 | GUSB (0.57) | GUSBMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL4518930 | 0.77 | SPR (0.55) | GUSBPDE5AMAPTMEN1KMT2A | |
| SCHEMBL13789318 | 0.77 | SMN1; SMN2 (0.74) | GUSBPDE5AMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8623127 | 0.76 | GUSB (1.00) | GUSBMAPTRAB9AALDH1A1KDM4E | |
| SCHEMBL13789326 | 0.76 | SMN1; SMN2 (0.50) | GUSBPDE5AMAPTMEN1KMT2A | |
| SCHEMBL13789304 | 0.75 | SMN1; SMN2 (0.56) | PDE5AMAPTHTTRAB9ASMN1; SMN2 | |
| SCHEMBL13789402 | 0.75 | SMN1; SMN2 (0.59) | PDE5AMAPTHTTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102844320-B | Heterocyclic compounds | TAKEDA PHARMACEUTICAL CO.,LTD. (JP) | 2016-03-23 | — | — | CN | disclosed |