Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of 2-Chloropyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.76 |
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | LOX | P28300 | 1/20 | 0.43 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.42 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | CCR1 | P32246 | 2/20 | 0.40 |
| ▸ | CCR5 | P51681 | 2/20 | 0.40 |
| ▸ | CCR8 | P51685 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Chloropyridine SCHEMBL27904570 | 0.89 | TDP1 (0.67) | TDP1HRH1LOXLOXL3LOXL2 | |
| 2-Chloropyridine SCHEMBL28283275 | 0.87 | TDP1 (1.00) | TDP1NOS3NOS1NOS2PI4KA | |
| 2-Chloropyridine SCHEMBL10690176 | 0.87 | TDP1 (1.00) | TDP1NOS3NOS1NOS2PI4KA | |
| 2-Chloropyridine SCHEMBL16637 | 0.87 | — | — | |
| 2-Chloropyridine SCHEMBL29402311 | 0.87 | — | — | |
| 2-Chloropyridine SCHEMBL11389784 | 0.87 | — | — | |
| 2-Chloropyridine SCHEMBL29185397 | 0.85 | — | — | |
| 2-Chloropyridine SCHEMBL1647769 | 0.85 | TDP1 (0.55) | TDP1HRH1LOXLOXL3LOXL2 | |
| 2-Chloropyridine SCHEMBL457535 | 0.85 | — | — | |
| 2-Chloropyridine SCHEMBL1935752 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105348258-B | Synthetic method of 2-chloro-5- ((2- (nitromethylene) imidazoline-1-yl) methyl) pyridine | 上海生农生化制品股份有限公司 | 2020-10-23 | — | — | CN | claimed |
| CN-105348258-B | Synthetic method of 2-chloro-5- ((2- (nitromethylene) imidazoline-1-yl) methyl) pyridine | 上海生农生化制品股份有限公司 | 2020-10-23 | — | — | CN | disclosed |
| CN-105348258-B | Synthetic method of 2-chloro-5- ((2- (nitromethylene) imidazoline-1-yl) methyl) pyridine | 上海生农生化制品股份有限公司 | 2020-10-23 | — | — | CN | disclosed |
| CN-104447690-B | The method of one pot process chloropyridine Nitromethylene imidazolidine | 上海生农生化制品股份有限公司 | 2019-10-11 | — | — | CN | disclosed |
| CN-105949172-A | 2-pyridyl-1-substitued imidazoline corrosion inhibitors as well as preparation method and application thereof | 广东工业大学 | 2016-09-21 | — | — | CN | disclosed |
| CN-105348258-A | Synthetic method of 2-chlorine-5-((2-(nitromethylene)imidazoline-1-yl)methyl)pyridine | SHANGHAI SHENGNONG PESTICIDE CO LTD | 2016-02-24 | — | — | CN | disclosed |