⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12060944 | 0.73 | — | — | |
| SCHEMBL3414852 | 0.70 | — | — | |
| SCHEMBL12060723 | 0.65 | DPP4 (0.31) | — | |
| SCHEMBL12060724 | 0.65 | — | — | |
| SCHEMBL24371224 | 0.63 | — | — | |
| SCHEMBL20434443 | 0.63 | — | — | |
| SCHEMBL3461873 | 0.62 | — | — | |
| SCHEMBL14215558 | 0.62 | — | — | |
| SCHEMBL13271077 | 0.59 | — | — | |
| SCHEMBL18016490 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2981542-B1 | 2',4'-FLUORO NUCLEOSIDES FOR THE TREATMENT OF HCV | IDENIX PHARMACEUTICALS LLC (US) | 2021-09-15 | — | — | EP | disclosed |
| US-20120157514-A1 | OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNAS | Regulus Therapeutics Inc. (US) | 2012-06-21 | — | — | US | disclosed |
| US-8133876-B2 | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs | Regulus Therapeutics Inc. (US) | 2012-03-13 | — | — | US | disclosed |
| US-8110558-B2 | Oligomeric compounds and compositions for use in modulation of small non-coding RNAS | Regulus Therapeutics Inc. (US) | 2012-02-07 | — | — | US | disclosed |
| US-20120029049-A1 | Antisense Modulation of Superoxide Dismutase 1, Soluble Expression | Isis Corporation (US) | 2012-02-02 | — | — | US | disclosed |
| US-20110224277-A1 | Oligomeric Compounds And Compositions For Use In Modulation Of Small Non-Coding RNAs | REGULUS THERAPEUTICS, LLC. (US) | 2011-09-15 | — | — | US | disclosed |
| US-20110171730-A1 | Conjugates For Use In Hepatocyte Free Uptake Assays | ISIS PHARMACEUTICALS, INC. (US) | 2011-07-14 | — | — | US | disclosed |
| US-7897582-B2 | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein | ISIS PHARMACEUTICALS, INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-7812149-B2 | Comprises nucleotide sequences for use in gene expression inhibition, viral defense, transposon silencing and treatment of metabolic disorders; antisense agents | ISIS PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| US-7713944-B2 | Oligomers comprising activated disulfides which bind to plasma proteins and their use for delivery to cells | ISIS PHARMACEUTICALS, INC. (US) | 2010-05-11 | — | — | US | disclosed |
| US-20090291906-A1 | Oligomeric Compounds And Compositions For Use In Modulation Of Small Non-Coding RNAs | REGULUS THERAPEUTICS, LLC. (US) | 2009-11-26 | — | — | US | disclosed |
| US-20090291907-A1 | Oligomeric Compounds And Compositions For Use In Modulation Of Small Non-Coding RNAs | REGULUS THERAPEUTICS, LLC. (US) | 2009-11-26 | — | — | US | disclosed |
| US-20090286969-A1 | Oligomeric Compounds And Compositions For Use In Modulation Of Small Non-Coding RNAs | REGULUS THERAPEUTICS, LLC. (US) | 2009-11-19 | — | — | US | disclosed |
| US-20090203132-A1 | PYRROLIDINYL GROUPS FOR ATTACHING CONJUGATES TO OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2009-08-13 | — | — | US | disclosed |
| US-20080027019-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE MODULATION OF THE EXPRESSION OF B7 PROTEIN | ISIS PHARMACEUTICALS, INC. (US) | 2008-01-31 | — | — | US | disclosed |