⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20434443 | 0.83 | — | — | |
| SCHEMBL21264897 | 0.80 | — | — | |
| SCHEMBL12899559 | 0.76 | — | — | |
| SCHEMBL11410719 | 0.76 | — | — | |
| SCHEMBL21972024 | 0.75 | — | — | |
| SCHEMBL25881700 | 0.74 | F10 (0.30) | — | |
| SCHEMBL12060944 | 0.73 | — | — | |
| SCHEMBL23374138 | 0.72 | KDM4E (0.30) | — | |
| SCHEMBL10149500 | 0.72 | KDM4E (0.30) | — | |
| SCHEMBL280523 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158779-B2 | Antiviral nucleosides | MEDIVIR AB (SE) | 2012-04-17 | — | — | US | disclosed |
| US-20110172410-A1 | ANTIVIRAL NUCLEOSIDES | MEDIVIR AB (SE) | 2011-07-14 | — | — | US | disclosed |
| WO-2011067195-A1 | BIOMARKERS FOR PREDICTING SUSTAINED RESPONSE TO HCV TREATMENT | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-09 | — | — | WO | disclosed |
| WO-2011058084-A1 | BIOMARKERS FOR PREDICTING RAPID RESPONSE TO HCV TREATMENT | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-19 | — | — | WO | disclosed |
| US-7935681-B2 | Antiviral nucleosides | MEDIVIR AB (SE) | 2011-05-03 | — | — | US | disclosed |
| US-20110015148-A1 | ANTIVIRAL NUCLEOSIDES | MEDIVIR AB (SE) | 2011-01-20 | — | — | US | disclosed |
| WO-2010069809-A1 | BIOMARKERS FOR HCV TREATMENT RESPONSE | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-24 | — | — | WO | disclosed |
| WO-2008043704-A1 | HCV NUCLEOSIDE INHIBITOR | MEDIVIR AB (SE) | 2008-04-17 | — | — | WO | disclosed |
| WO-2007065829-A1 | ANTIVIRAL NUCLEOSIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-14 | — | — | WO | disclosed |