Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 5/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL566704 | 0.96 | — | — | |
| Bicarbonate SCHEMBL7192999 | 0.92 | — | — | |
| Bicarbonate SCHEMBL28649909 | 0.92 | ALDH1A1 (0.50) | ALDH1A1CA1CA2CA9TSHR | |
| Bicarbonate SCHEMBL28605195 | 0.92 | ALDH1A1 (0.50) | ALDH1A1CA1CA2CA9TSHR | |
| Bicarbonate SCHEMBL28781234 | 0.92 | ALDH1A1 (0.50) | ALDH1A1CA1CA2CA9TSHR | |
| Bicarbonate SCHEMBL29206257 | 0.92 | ALDH1A1 (0.50) | ALDH1A1CA1CA2CA9TSHR | |
| Bicarbonate SCHEMBL28882374 | 0.92 | ALDH1A1 (0.50) | ALDH1A1CA1CA2CA9TSHR | |
| SCHEMBL27553773 | 0.88 | ALDH1A1 (0.54) | ALDH1A1CA1CA2CA9TSHR | |
| SCHEMBL37752 | 0.88 | — | — | |
| Rubidium SCHEMBL7045613 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105377807-A | Fluorinated carbonates comprising double bond-containing groups, methods for their manufacture and uses thereof | SOLVAY | 2016-03-02 | — | — | CN | disclosed |