Phosphine

Phosphine

SCHEMBL28053764

COO[Si](O)(OOC)Oc1ccccc1.P

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA4 P22748 1/20 0.41
LTA4H P09960 3/20 0.35
TSHR P16473 2/20 0.33
CA5A P35218 1/20 0.32
CA5B Q9Y2D0 1/20 0.32
LMNA P02545 1/20 0.31
NR1H2 P55055 1/20 0.31
BAX Q07812 1/20 0.31
HPGD P15428 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
PAX8 Q06710 1/20 0.31
TDP1 Q9NUW8 2/20 0.31
CES2 O00748 1/20 0.31
CES1 P23141 1/20 0.31
ATM Q13315 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
ALDH1A1 P00352 1/20 0.30
RECQL P46063 1/20 0.30
SRC P12931 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28053677 0.98 CA4 (0.42) CA4LTA4HTSHRCA5ACA5B
Phosphine SCHEMBL28057887 0.92 CA4 (0.38) CA4LTA4HTSHRCA5ACA5B
SCHEMBL28193743 0.80 CA4 (0.46) CA4LTA4HTSHRCA5ACA5B
SCHEMBL1217901 0.79 LTA4H (0.45) CA4LTA4HTSHRCA5ACA5B
Fluoride SCHEMBL27845931 0.77 LTA4H (0.43) CA4LTA4HTSHRCA5ACA5B
SCHEMBL1348055 0.76 CA4 (0.46) CA4LTA4HTSHRCA5ACA5B
SCHEMBL1347951 0.76 CA4 (0.46) CA4LTA4HTSHRCA5ACA5B
SCHEMBL1608971 0.76 CA4 (0.46) CA4LTA4HTSHRCA5ACA5B
SCHEMBL28252912 0.73 CA4 (0.39) CA4LTA4HTSHRCA5ACA5B
Naphthalene SCHEMBL28255506 0.73 CYP2A6 (0.40) CA4TSHRHPGDTDP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111073348-A Preparation method of flame-retardant modified silica micropowder for halogen-free copper-clad plate 江苏联瑞新材料股份有限公司 2020-04-28 CN claimed
CN-105254675-B Phenyl dimethoxy silicic acid phosphine heterocycle methyl compound and preparation method thereof 苏州科技大学 2018-04-27 CN claimed
CN-105254675-A Phenyl dimethoxy silicate phosphonic heterocyclic methyl ester compound and preparation method thereof USTC UNIV SCIENCE TECH CN 2016-01-20 CN claimed
CN-111073348-A Preparation method of flame-retardant modified silica micropowder for halogen-free copper-clad plate 江苏联瑞新材料股份有限公司 2020-04-28 CN disclosed
CN-111073348-A Preparation method of flame-retardant modified silica micropowder for halogen-free copper-clad plate 江苏联瑞新材料股份有限公司 2020-04-28 CN disclosed
CN-105254675-B Phenyl dimethoxy silicic acid phosphine heterocycle methyl compound and preparation method thereof 苏州科技大学 2018-04-27 CN disclosed
CN-105254675-B Phenyl dimethoxy silicic acid phosphine heterocycle methyl compound and preparation method thereof 苏州科技大学 2018-04-27 CN disclosed
CN-105254675-B Phenyl dimethoxy silicic acid phosphine heterocycle methyl compound and preparation method thereof 苏州科技大学 2018-04-27 CN disclosed
CN-105254675-A Phenyl dimethoxy silicate phosphonic heterocyclic methyl ester compound and preparation method thereof USTC UNIV SCIENCE TECH CN 2016-01-20 CN disclosed