Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 12/20 | 0.54 |
| ▸ | IGF1R | P08069 | 3/20 | 0.45 |
| ▸ | INSR | P06213 | 2/20 | 0.45 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28053990 | 0.88 | ALK (0.59) | EGFRALKIGF1RINSRBRD4 | |
| SCHEMBL28053885 | 0.86 | ALK (0.54) | ALKIGF1RINSRBRD4TTK | |
| SCHEMBL28053893 | 0.83 | ALK (0.63) | EGFRALKIGF1RINSRKCNH2 | |
| SCHEMBL28053989 | 0.83 | ALK (0.63) | EGFRALKIGF1RINSRKCNH2 | |
| SCHEMBL16752907 | 0.81 | ALK (0.80) | ALK | |
| SCHEMBL28053876 | 0.77 | ALK (0.64) | EGFRALK | |
| SCHEMBL28053986 | 0.76 | EGFR (0.80) | EGFRALKTTK | |
| SCHEMBL30340921 | 0.75 | IGF1R (0.54) | EGFRALKIGF1RINSRCDK2 | |
| SCHEMBL28782059 | 0.74 | EGFR (0.50) | EGFRALKDYRK1BTTK | |
| SCHEMBL4820325 | 0.72 | GAA (0.62) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384694-B | Substituted aminopyrimidine derivative and preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2020-09-04 | — | — | CN | disclosed |
| CN-105384694-A | Substituted aminopyrimidine derivative, preparation method therefor and pharmaceutical application thereof | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |