Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 13/20 | 0.54 |
| ▸ | INSR | P06213 | 2/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28053862 | 0.86 | EGFR (0.54) | ALKINSRIGF1RBRD4TTK | |
| SCHEMBL28053990 | 0.86 | ALK (0.59) | ALKINSRIGF1RBRD4PTK2 | |
| SCHEMBL28053989 | 0.83 | ALK (0.63) | ALKINSRIGF1RTTKLRRK2 | |
| SCHEMBL28053893 | 0.83 | ALK (0.63) | ALKINSRIGF1RPTK2TTK | |
| SCHEMBL16752907 | 0.81 | ALK (0.80) | ALK | |
| SCHEMBL28053876 | 0.77 | ALK (0.64) | ALK | |
| SCHEMBL12718996 | 0.77 | PTK2 (0.44) | ALKINSRIGF1RPTK2TTK | |
| SCHEMBL28053999 | 0.76 | EGFR (0.65) | ALKTTK | |
| SCHEMBL30340921 | 0.73 | IGF1R (0.54) | ALKINSRIGF1RTTKLRRK2 | |
| SCHEMBL4820325 | 0.72 | GAA (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384694-B | Substituted aminopyrimidine derivative and preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2020-09-04 | — | — | CN | disclosed |
| CN-105384694-A | Substituted aminopyrimidine derivative, preparation method therefor and pharmaceutical application thereof | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |