Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.53 |
| ▸ | BTK | Q06187 | 11/20 | 0.46 |
| ▸ | TYK2 | P29597 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | TEC | P42680 | 1/20 | 0.43 |
| ▸ | TXK | P42681 | 1/20 | 0.43 |
| ▸ | BMX | P51813 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28054159 | 0.85 | JAK2 (0.47) | JAK2BTKTYK2AURKALCK | |
| SCHEMBL28054171 | 0.85 | JAK2 (0.47) | JAK2BTKTYK2DYRK1AJAK1 | |
| SCHEMBL16320530 | 0.83 | BTK (0.43) | JAK2BTKTYK2AURKALCK | |
| SCHEMBL19279114 | 0.82 | BTK (0.54) | BTK | |
| SCHEMBL19279115 | 0.82 | BTK (0.54) | BTK | |
| SCHEMBL123552 | 0.81 | JAK2 (0.45) | JAK2BTKTYK2AURKALCK | |
| SCHEMBL18976381 | 0.81 | BTK (0.43) | JAK2BTKJAK3 | |
| SCHEMBL18975844 | 0.81 | EIF4A3 (0.46) | JAK2BTKTYK2AURKALCK | |
| SCHEMBL16320240 | 0.80 | BTK (0.57) | JAK2BTK | |
| SCHEMBL16320377 | 0.80 | BTK (0.54) | JAK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105358546-A | Substituted tetrahydrocarbazole and carbazole carboxamide compounds useful as kinase inhibitors | BRISTOL MYERS SQUIBB CO | 2016-02-24 | — | — | CN | disclosed |