Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 9/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28054082 | 0.85 | JAK2 (0.53) | JAK2DYRK1ABTKPARP1JAK1 | |
| SCHEMBL28054159 | 0.85 | JAK2 (0.47) | JAK2DYRK1ABTKPARP1TYK2 | |
| SCHEMBL16319903 | 0.83 | ALDH1A1 (0.44) | JAK2DYRK1ABTKPARP1 | |
| SCHEMBL19279567 | 0.82 | BTK (0.53) | JAK2BTK | |
| SCHEMBL123552 | 0.81 | JAK2 (0.45) | JAK2DYRK1ABTKTYK2 | |
| SCHEMBL16320628 | 0.80 | BTK (0.56) | JAK2BTK | |
| SCHEMBL141907 | 0.80 | JAK2 (0.56) | JAK2DYRK1ABTKPARP1JAK1 | |
| SCHEMBL19279087 | 0.76 | PBRM1 (0.48) | DYRK1ABTKPARP1 | |
| SCHEMBL18138214 | 0.74 | DYRK1A (0.47) | JAK2DYRK1APARP1JAK1JAK3 | |
| SCHEMBL18975629 | 0.73 | BTK (0.43) | JAK2BTKTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105358546-A | Substituted tetrahydrocarbazole and carbazole carboxamide compounds useful as kinase inhibitors | BRISTOL MYERS SQUIBB CO | 2016-02-24 | — | — | CN | disclosed |