Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Phosphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | LAP3 | P28838 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL5029340 | 0.98 | HIF1A (0.52) | HIF1AALDH1A1TSHRCYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL8086728 | 0.93 | HIF1A (0.52) | HIF1AALDH1A1TSHRCYP1A2CYP2D6 | |
| Bromide SCHEMBL161462 | 0.93 | HIF1A (0.52) | HIF1AALDH1A1TSHRCYP1A2CYP2D6 | |
| SCHEMBL8376846 | 0.86 | HIF1A (0.46) | HIF1AALDH1A1TSHRCYP1A2CYP2D6 | |
| SCHEMBL8378542 | 0.86 | HIF1A (0.46) | HIF1AALDH1A1TSHRCYP1A2CYP2D6 | |
| SCHEMBL8374701 | 0.86 | HIF1A (0.46) | HIF1AALDH1A1TSHRCYP1A2CYP2D6 | |
| SCHEMBL8606124 | 0.86 | HIF1A (0.46) | HIF1AALDH1A1TSHRCYP1A2CYP2D6 | |
| Phosphine SCHEMBL28150214 | 0.80 | HIF1A (0.55) | HIF1AALDH1A1TSHRCYP1A2CYP2D6 | |
| Iodide SCHEMBL9482433 | 0.79 | HIF1A (0.48) | HIF1AALDH1A1TSHRCYP1A2CYP2D6 | |
| Iodide SCHEMBL9482438 | 0.79 | HIF1A (0.48) | HIF1AALDH1A1TSHRCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103951850-B | Photothermal response system, resin material and photothermal response intelligent glass | FU GUODONG (CN) | 2016-04-13 | — | — | CN | disclosed |