Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 5/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | CHUK | O15111 | 2/20 | 0.38 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL100645 | 0.87 | MAPK14 (0.48) | PRKCIMAPK1AKT2NUDT1AXL | |
| SCHEMBL29540449 | 0.87 | PRKCI (0.46) | PRKCIAKT2NUDT1AXLIKBKB | |
| SCHEMBL102456 | 0.87 | PRKCI (0.46) | PRKCIAKT2NUDT1AXLIKBKB | |
| SCHEMBL29540558 | 0.87 | MAPK14 (0.48) | PRKCIMAPK1AKT2NUDT1AXL | |
| SCHEMBL29540619 | 0.87 | JAK2 (0.52) | PRKCIMAPK1AKT2NUDT1IKBKB | |
| SCHEMBL100939 | 0.87 | JAK2 (0.52) | PRKCIMAPK1AKT2NUDT1IKBKB | |
| SCHEMBL5134218 | 0.86 | CDC7 (0.44) | PRKCIAKT2NUDT1IKBKBCHUK | |
| SCHEMBL29540798 | 0.84 | MAPK1 (0.47) | PRKCIMAPK1AKT2ROCK1CIT | |
| SCHEMBL100644 | 0.84 | MAPK1 (0.47) | PRKCIMAPK1AKT2ROCK1CIT | |
| SCHEMBL99492 | 0.84 | PRKCI (0.43) | PRKCIRIPK1AKT2NUDT1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103254190-B | Heteroaryl substituted pyrrolo-[2,3-b] pyridine and pyrrolo-[2,3-b] pyrimidine as Janus inhibitors of kinases | 因塞特控股公司 | 2016-12-07 | — | — | CN | disclosed |
| CN-103214484-B | Pyrrolo-[2,3-b] pyridine replaced as the heteroaryl of Janus inhibitors of kinases and pyrrolo-[2,3-b] pyrimidine | 因塞特控股公司 | 2016-07-06 | — | — | CN | disclosed |