Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.54 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.54 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.54 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 3/20 | 0.48 |
| ▸ | JAK2 | O60674 | 8/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
| ▸ | CIT | O14578 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5134407 | 0.86 | AURKB (0.57) | AURKAAURKBINCENPTPX2GRM4 | |
| Trifluoroacetic Acid SCHEMBL100051 | 0.85 | AURKA (0.49) | AURKAAURKBINCENPTPX2GRM4 | |
| SCHEMBL98741 | 0.84 | AURKA (0.55) | AURKAAURKBINCENPTPX2GRM4 | |
| SCHEMBL13774666 | 0.84 | AURKB (0.62) | AURKAAURKBINCENPTPX2GRM4 | |
| SCHEMBL100576 | 0.84 | AURKB (0.62) | AURKAAURKBINCENPTPX2GRM4 | |
| SCHEMBL15399202 | 0.84 | JAK2 (0.63) | JAK1JAK2 | |
| SCHEMBL99617 | 0.84 | AURKA (0.49) | AURKAAURKBINCENPTPX2GRM4 | |
| SCHEMBL99011 | 0.83 | AURKB (0.60) | AURKAAURKBINCENPTPX2GRM4 | |
| SCHEMBL4094038 | 0.82 | JAK2 (0.51) | AURKAAURKBINCENPTPX2GRM4 | |
| SCHEMBL14845593 | 0.82 | AURKB (0.59) | AURKAAURKBINCENPTPX2GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103214484-B | Pyrrolo-[2,3-b] pyridine replaced as the heteroaryl of Janus inhibitors of kinases and pyrrolo-[2,3-b] pyrimidine | 因塞特控股公司 | 2016-07-06 | — | — | CN | disclosed |