Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 5/20 | 0.59 |
| ▸ | AURKA | O14965 | 4/20 | 0.59 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.59 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.59 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.52 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 2/20 | 0.47 |
| ▸ | CHUK | O15111 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 5/20 | 0.47 |
| ▸ | CIT | O14578 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 5/20 | 0.45 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL100576 | 0.88 | AURKB (0.62) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL13774666 | 0.88 | AURKB (0.62) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL99011 | 0.87 | AURKB (0.60) | AURKBAURKAINCENPTPX2GRM4 | |
| Trifluoroacetic Acid SCHEMBL5134407 | 0.84 | AURKB (0.57) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL98741 | 0.83 | AURKA (0.55) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL13541161 | 0.82 | AURKB (0.63) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL29540487 | 0.82 | AURKB (0.60) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL101177 | 0.82 | AURKB (0.60) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL28107488 | 0.82 | AURKB (0.57) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL28055284 | 0.82 | AURKA (0.54) | AURKBAURKAINCENPTPX2GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415362-B2 | Pyrazolyl substituted pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE CORPORATION (US) | 2013-04-09 | — | — | US | disclosed |