Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRF | P10586 | 1/20 | 0.56 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | CRHBP | P24387 | 2/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6097282 | 0.81 | CYP19A1 (0.51) | MEN1KMT2AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL29048560 | 0.80 | MAPT (0.63) | PTPRFPTPN2PTPN1PTPN11MEN1 | |
| SCHEMBL6170460 | 0.78 | FLT1 (0.47) | MEN1KMT2AMAPTGAACRHBP | |
| SCHEMBL18610468 | 0.77 | PTPRF (0.62) | PTPRFPTPN2PTPN1PTPN11MEN1 | |
| SCHEMBL1804701 | 0.76 | NPC1 (0.58) | PTPRFPTPN2PTPN1PTPN11MEN1 | |
| SCHEMBL17141871 | 0.74 | PTPRF (0.59) | PTPRFPTPN2PTPN1PTPN11MEN1 | |
| SCHEMBL4442994 | 0.74 | CCR8 (0.49) | CYP19A1LMNA | |
| Acetanilide SCHEMBL27366940 | 0.72 | KMT2A (0.69) | MEN1KMT2AMAPTGAACYP1A2 | |
| SCHEMBL627885 | 0.72 | PTPRF (1.00) | PTPRFPTPN2PTPN1PTPN11MEN1 | |
| SCHEMBL1888641 | 0.72 | ABCG2 (0.65) | MEN1KMT2AMAPTGAACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105399733-A | Novel quinazoline derivative LU1504 and preparing method and application thereof | NANJING GENERAL HOSPITAL NANJING MILITARY AREA COMMAND PLA | 2016-03-16 | — | — | CN | claimed |
| CN-105399689-A | Novel quinazoline derivative LU1503 and preparing method and application thereof | NANJING GENERAL HOSPITAL NANJING MILITARY AREA COMMAND PLA | 2016-03-16 | — | — | CN | claimed |
| CN-105399733-A | Novel quinazoline derivative LU1504 and preparing method and application thereof | NANJING GENERAL HOSPITAL NANJING MILITARY AREA COMMAND PLA | 2016-03-16 | — | — | CN | disclosed |
| CN-105399689-A | Novel quinazoline derivative LU1503 and preparing method and application thereof | NANJING GENERAL HOSPITAL NANJING MILITARY AREA COMMAND PLA | 2016-03-16 | — | — | CN | disclosed |