Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.66 |
| ▸ | ITK | Q08881 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16336723 | 0.88 | BTK (0.68) | BTK | |
| SCHEMBL16336932 | 0.87 | BTK (0.62) | BTK | |
| SCHEMBL16336353 | 0.86 | BTK (0.71) | BTK | |
| SCHEMBL16338185 | 0.84 | BTK (0.71) | BTKJAK3 | |
| SCHEMBL16336468 | 0.83 | BTK (0.67) | BTK | |
| SCHEMBL28055955 | 0.80 | BTK (0.45) | BTK | |
| SCHEMBL16336935 | 0.80 | BTK (1.00) | BTK | |
| SCHEMBL16334895 | 0.78 | BTK (0.71) | BTKJAK3 | |
| SCHEMBL29782625 | 0.77 | BTK (1.00) | BTKITKJAK2JAK3 | |
| SCHEMBL17699522 | 0.77 | BTK (1.00) | BTKITKJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105530932-B | Primary formamide as BTK inhibitor | 艾伯维公司 | 2019-09-27 | — | — | CN | claimed |
| CN-105530932-A | Primary carboxamides as BIK inhibitors | ABBVIE INC | 2016-04-27 | — | — | CN | claimed |
| CN-105530932-B | Primary formamide as BTK inhibitor | 艾伯维公司 | 2019-09-27 | — | — | CN | disclosed |
| CN-105530932-A | Primary carboxamides as BIK inhibitors | ABBVIE INC | 2016-04-27 | — | — | CN | disclosed |