Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 17/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16336069 | 0.85 | BTK (0.46) | BTKPARP1 | |
| SCHEMBL21008529 | 0.84 | BTK (0.40) | BTK | |
| SCHEMBL16336539 | 0.84 | BTK (0.41) | BTKPARP1 | |
| SCHEMBL16336682 | 0.83 | BTK (0.54) | BTKPARP1 | |
| SCHEMBL28055902 | 0.80 | BTK (0.66) | BTK | |
| SCHEMBL16336244 | 0.79 | BTK (0.42) | BTKPARP1 | |
| SCHEMBL16338011 | 0.78 | BTK (0.47) | BTKPARP1 | |
| SCHEMBL28321282 | 0.77 | TP53 (0.36) | — | |
| SCHEMBL16337932 | 0.75 | BTK (0.70) | BTK | |
| SCHEMBL16337236 | 0.73 | BTK (0.50) | BTKPARP1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105530932-B | Primary formamide as BTK inhibitor | 艾伯维公司 | 2019-09-27 | — | — | CN | disclosed |
| CN-105530932-A | Primary carboxamides as BIK inhibitors | ABBVIE INC | 2016-04-27 | — | — | CN | disclosed |