Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.35 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.35 |
| ▸ | RBBP9 | O75884 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 3/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27964022 | 0.81 | RBBP9 (0.41) | HPGDALDH1A1MEN1KMT2ARBBP9 | |
| SCHEMBL16334091 | 0.81 | USP30 (0.55) | ADORA3ADORA2AADORA2BUSP30PBK | |
| SCHEMBL16337990 | 0.81 | USP30 (0.55) | ADORA3ADORA2AADORA2BUSP30PBK | |
| SCHEMBL16334556 | 0.76 | TNKS (0.42) | TNKSHPGDALDH1A1MEN1TSHR | |
| SCHEMBL28975852 | 0.75 | ALDH1A1 (0.43) | HPGDALDH1A1MEN1KMT2ARBBP9 | |
| SCHEMBL12181482 | 0.75 | MEN1 (0.54) | TNKSHPGDALDH1A1MEN1TSHR | |
| SCHEMBL5738394 | 0.73 | TSHR (0.60) | TNKSHPGDALDH1A1MEN1TSHR | |
| SCHEMBL27759531 | 0.73 | USP30 (0.49) | ALDH1A1MEN1KMT2AUSP30HDAC4 | |
| SCHEMBL28290681 | 0.72 | DRD4 (0.40) | ALDH1A1 | |
| SCHEMBL27723938 | 0.72 | CA1 (0.37) | ALDH1A1USP30BTKGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105530932-B | Primary formamide as BTK inhibitor | 艾伯维公司 | 2019-09-27 | — | — | CN | disclosed |
| CN-105530932-A | Primary carboxamides as BIK inhibitors | ABBVIE INC | 2016-04-27 | — | — | CN | disclosed |