Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gluconic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hippuric Acid SCHEMBL3710131 | 0.93 | KDM4E (0.44) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Demannose SCHEMBL529006 | 0.81 | KDM4E (0.40) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Demannose SCHEMBL6279048 | 0.80 | ALDH1A1 (0.39) | KDM4EMAPTHIF1ASMN1; SMN2NPC1 | |
| Glucuronic Acid SCHEMBL10823159 | 0.78 | PDE4A (0.73) | PDE4AKDM4EGAAALDH1A1 | |
| Gluconic Acid SCHEMBL20815121 | 0.78 | PDE4A (0.73) | PDE4AKDM4EGAAALDH1A1 | |
| Gluconic Acid SCHEMBL4389427 | 0.78 | PDE4A (0.73) | PDE4AKDM4EGAAALDH1A1 | |
| Gluconic Acid SCHEMBL2785483 | 0.78 | PDE4A (0.73) | PDE4AKDM4EGAAALDH1A1 | |
| Gluconic Acid SCHEMBL20741140 | 0.78 | PDE4A (0.73) | PDE4AKDM4EGAAALDH1A1 | |
| Gluconic Acid SCHEMBL861904 | 0.78 | PDE4A (0.73) | PDE4AKDM4EGAAALDH1A1 | |
| Gluconic Acid SCHEMBL14841816 | 0.78 | PDE4A (0.73) | PDE4AKDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106065009-A | As the compound of hepatitis c inhibitor and the application in medicine thereof | 广东东阳光药业有限公司 | 2016-11-02 | — | — | CN | disclosed |
| CN-105829286-A | Heteroaryl butanoic acid derivatives as LTA4H inhibitors | 诺华股份有限公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-103097385-B | IP receptor stimulating agent heterocyclic compound | 诺华股份有限公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-105777756-A | Heteroaryl compound and application thereof in medicines | 广东东阳光药业有限公司 | 2016-07-20 | — | — | CN | disclosed |
| CN-105732637-A | Hetero-aromatic compounds and applications thereof in pharmacy | 广东东阳光药业有限公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-103814027-B | Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and their use as C5A receptor modulators | 诺华股份有限公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-105732636-A | Hetero-aromatic compounds and applications thereof in pharmacy | 广东东阳光药业有限公司 | 2016-07-06 | — | — | CN | disclosed |