Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
| ▸ | ADK | P55263 | 10/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16236406 | 0.87 | RET (0.52) | FGFR1FGFR4ADKMTORRAB9A | |
| SCHEMBL17818405 | 0.87 | SRC (0.48) | FGFR1FGFR4ADKMTORRAB9A | |
| SCHEMBL27217643 | 0.86 | HASPIN (0.53) | FGFR1ADKMTORRAB9AHASPIN | |
| SCHEMBL20981728 | 0.82 | EGFR (0.53) | FGFR1FGFR4ADKMTORRAB9A | |
| SCHEMBL15720017 | 0.82 | EGFR (0.53) | FGFR1FGFR4ADKMTORRAB9A | |
| SCHEMBL20981818 | 0.82 | EGFR (0.53) | FGFR1FGFR4ADKMTORRAB9A | |
| SCHEMBL1444035 | 0.82 | SRC (0.64) | ADKMTORRAB9AHASPINFGFR2 | |
| SCHEMBL29503400 | 0.82 | SRC (0.64) | ADKMTORRAB9AHASPINFGFR2 | |
| SCHEMBL19743546 | 0.81 | MTOR (0.52) | FGFR1ADKMTORRAB9AEGFR | |
| SCHEMBL10225976 | 0.81 | ADK (0.47) | ADKMTORRAB9AHASPINEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105431436-A | Pyrrolo [2,3-D ] pyrimidine derivatives, processes for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2016-03-23 | — | — | CN | disclosed |