Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.49 |
| ▸ | DHODH | Q02127 | 3/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.45 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 2/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28057748 | 0.88 | ERN1 (0.49) | DHODHERN1CA12CA1CA2 | |
| SCHEMBL27716780 | 0.85 | TRIM24 (0.54) | MKNK1MKNK2 | |
| SCHEMBL31371753 | 0.82 | CA12 (0.50) | MKNK1MKNK2MYCERN1CA12 | |
| SCHEMBL1568517 | 0.80 | PARP1 (0.53) | CA12CA1CA2CA9CA14 | |
| SCHEMBL22367342 | 0.80 | MKNK1 (0.64) | MKNK1MKNK2DHODHAOC3ERN1 | |
| SCHEMBL23380281 | 0.80 | EGFR (0.55) | ERN1CA12CA1CA2CA9 | |
| SCHEMBL2589651 | 0.78 | ERN1 (0.60) | MKNK1MKNK2DHODHERN1 | |
| SCHEMBL3843982 | 0.78 | CA12 (0.42) | CA12CA1CA2CA9CA14 | |
| SCHEMBL3841296 | 0.78 | CA12 (0.48) | CA12CA1CA2CA9CA14 | |
| SCHEMBL11352929 | 0.77 | TAAR1 (0.52) | CA12CA1CA2CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105431436-B | Pyrrolo [2,3-D ] pyrimidine derivatives, processes for their preparation and their use as kinase inhibitors | 内尔维阿诺医学科学有限公司 | 2017-11-28 | — | — | CN | disclosed |
| CN-105431436-A | Pyrrolo [2,3-D ] pyrimidine derivatives, processes for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2016-03-23 | — | — | CN | disclosed |