Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.53 |
| ▸ | ICMT | O60725 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PI4KA | P42356 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16911970 | 0.87 | BRD4 (0.51) | GRM7BRD4BRD3ICMTLRRK2 | |
| SCHEMBL15652106 | 0.87 | ALDH1A1 (0.59) | GRM7BRD4BRD3ICMTLRRK2 | |
| SCHEMBL24497540 | 0.87 | KDM5A (0.52) | GRM7BRD4BRD3ICMTLRRK2 | |
| SCHEMBL16911718 | 0.85 | BRD4 (0.50) | GRM7BRD4BRD3ICMTLRRK2 | |
| SCHEMBL26545148 | 0.85 | BRD4 (0.47) | GRM7BRD4BRD3ICMTLRRK2 | |
| SCHEMBL27398722 | 0.85 | BRD4 (0.47) | GRM7BRD4BRD3ICMTLRRK2 | |
| SCHEMBL31051265 | 0.85 | BRD4 (0.47) | GRM7BRD4BRD3ICMTLRRK2 | |
| SCHEMBL16911318 | 0.85 | S1PR1 (0.54) | GRM7BRD4BRD3ICMTLRRK2 | |
| SCHEMBL27975555 | 0.85 | BRD4 (0.50) | GRM7BRD4BRD3ICMTLRRK2 | |
| SCHEMBL26544695 | 0.83 | BRD4 (0.46) | GRM7BRD4BRD3ICMTLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555780-B | SYK inhibitors | 吉利德科学公司 | 2018-01-23 | — | — | CN | disclosed |
| CN-105555780-A | Syk inhibitors | GILEAD SCIENCES INC | 2016-05-04 | — | — | CN | disclosed |