Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F9 | P00740 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | F12 | P00748 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 6/20 | 0.32 |
| ▸ | KHK | P50053 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.30 |
| ▸ | HTR2C | P28335 | 2/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL28320668 | 1.00 | DPP4 (0.40) | DPP4PLD1F2F9F10 | |
| Trifluoroacetic Acid SCHEMBL28058919 | 1.00 | DPP4 (0.40) | DPP4PLD1F2F9F10 | |
| SCHEMBL25381400 | 0.89 | PLD1 (0.44) | DPP4PLD1DPP7 | |
| SCHEMBL12413694 | 0.89 | PLD1 (0.44) | DPP4PLD1DPP7 | |
| SCHEMBL12414489 | 0.89 | PLD1 (0.44) | DPP4PLD1DPP7 | |
| Hydrochloric Acid SCHEMBL28320684 | 0.88 | PLD1 (0.43) | DPP4PLD1DPP7 | |
| Hydrochloric Acid SCHEMBL28320678 | 0.88 | PLD1 (0.43) | DPP4PLD1DPP7 | |
| Hydrochloric Acid SCHEMBL28320677 | 0.88 | PLD1 (0.43) | DPP4PLD1DPP7 | |
| Trifluoroacetic Acid SCHEMBL28943398 | 0.86 | DPP8 (0.40) | DPP4PLD1F2F9F10 | |
| Trifluoroacetic Acid SCHEMBL26113693 | 0.84 | DPP4 (0.38) | DPP4PLD1F2F9F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220389003-A1 | 4-SUBSTITUTED INDOLE AND INDAZOLE SULFONAMIDO DERIVATIVES AS PARG INHIBITORS | IDEAYA BIOSCIENCES, INC. | 2022-12-08 | — | — | US | disclosed |
| EP-4031249-A1 | 4-SUBSTITUTED INDOLE AND INDAZOLE SULFONAMIDO DERIVATIVES AS PARG INHIBITORS | Ideaya Biosciences, Inc. (US) | 2022-07-27 | — | — | EP | disclosed |
| CN-110088098-B | Quinazolinone PARP-1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-04-15 | — | — | CN | disclosed |
| CN-105461697-A | Quinazolinone PARP-1 inhibitors, medicinal composition containing inhibitors, and antitumor use of inhibitors | INST MATERIA MEDICA CAMS | 2016-04-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220389003-A1 | 4-SUBSTITUTED INDOLE AND INDAZOLE SULFONAMIDO DERIVATIVES AS PARG INHIBITORS | PARG, PARP11, PARN | DPP4 122/4885PLD1 3719/4885F2 1098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.