Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28080856 | 0.94 | KDM4E (0.40) | KDM4EKMT2ASMN1; SMN2MAPTMAPK1 | |
| Ethylene SCHEMBL28200918 | 0.91 | KDM4E (0.39) | KDM4EKMT2ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL6061540 | 0.73 | ALDH1A1 (0.36) | KDM4ESMN1; SMN2MAPTCYP3A4CES1 | |
| SCHEMBL28595923 | 0.73 | EPHX2 (0.57) | KDM4EKMT2ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL20955841 | 0.73 | MCL1 (0.43) | KDM4ESMN1; SMN2HPGDCES1GAA | |
| SCHEMBL1278317 | 0.73 | EPHX2 (0.57) | KDM4EKMT2ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL2438485 | 0.73 | EPHX2 (0.57) | KDM4EKMT2ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL7094216 | 0.73 | EPHX2 (0.57) | KDM4EKMT2ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL28414399 | 0.71 | MCL1 (0.42) | KDM4EKMT2ASMN1; SMN2HPGDMEN1 | |
| SCHEMBL28468123 | 0.71 | MAPK1 (0.61) | KDM4EKMT2ASMN1; SMN2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105407892-A | Pharmaceutical compositions of 7- (6- (2-hydroxypropan-2-yl) pyridin-3-yl) -1- ((trans) -4-methoxycyclohexyl) -3, 4-dihydropyrazino [2,3-B ] pyrazin-2 (1H) -one, solid forms thereof, and methods of their use | SIGNAL PHARM LLC | 2016-03-16 | — | — | CN | claimed |
| CN-105407892-B | Pharmaceutical composition of compound, solid form thereof and methods of use thereof | 西格诺药品有限公司 | 2019-05-07 | — | — | CN | disclosed |
| CN-105407892-A | Pharmaceutical compositions of 7- (6- (2-hydroxypropan-2-yl) pyridin-3-yl) -1- ((trans) -4-methoxycyclohexyl) -3, 4-dihydropyrazino [2,3-B ] pyrazin-2 (1H) -one, solid forms thereof, and methods of their use | SIGNAL PHARM LLC | 2016-03-16 | — | — | CN | disclosed |