Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.37 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1015020 | 0.98 | HSD11B1 (0.52) | HSD11B1KDM4EGLAHTTKMT2A | |
| SCHEMBL1015670 | 0.92 | HSD11B1 (0.50) | HSD11B1KDM4EKMT2ASMN1; SMN2TDP1 | |
| SCHEMBL1013142 | 0.82 | HSD11B1 (0.52) | HSD11B1KDM4EKMT2AHPGD | |
| SCHEMBL1014941 | 0.81 | KMT2A (0.43) | HSD11B1KDM4EGLAHTTKMT2A | |
| SCHEMBL1014340 | 0.79 | KDM4E (0.40) | HSD11B1KDM4EGLAHTTKMT2A | |
| SCHEMBL1587409 | 0.79 | KMT2A (0.44) | HSD11B1KDM4EGLAHTTKMT2A | |
| SCHEMBL1018048 | 0.79 | HSD11B1 (0.43) | HSD11B1KDM4EHTTKMT2ATDP1 | |
| SCHEMBL1013190 | 0.79 | KDM4E (0.37) | HSD11B1KDM4EGLAHTTKMT2A | |
| SCHEMBL6991254 | 0.79 | KDM4E (0.38) | HSD11B1KDM4EGLAHTTKMT2A | |
| SCHEMBL3825584 | 0.78 | HSD11B1 (0.49) | HSD11B1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814022-B | Condensed bicyclic heteroaromatic derivative as TNF active regulators | UCB生物制药私人有限公司 | 2018-09-28 | — | — | CN | disclosed |
| CN-105814051-B | Tetrahydroimidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2018-09-25 | — | — | CN | disclosed |
| CN-105814054-B | Condensed imidazole and pyrazole derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-09-25 | — | — | CN | disclosed |
| CN-105814025-B | Tetrahydrobenzimidazderivative derivative as TNF active regulators | UCB生物制药私人有限公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-105814059-B | Imidazo pyrimidine derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-04-03 | — | — | CN | disclosed |
| CN-105814046-B | Imidazopyridine derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-01-30 | — | — | CN | disclosed |
| CN-105814061-B | Imidazopyridazine derivative as TNF active regulators | UCB生物制药私人有限公司 | 2018-01-26 | — | — | CN | disclosed |
| CN-105814052-B | Imidazopyridine derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-01-12 | — | — | CN | disclosed |
| CN-105814056-B | purine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2017-10-10 | — | — | CN | disclosed |
| CN-105814045-B | Imidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2017-08-25 | — | — | CN | disclosed |
| CN-105829307-A | TETRAHYDROIMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB生物制药私人有限公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-105814059-A | Imidazopyrimidine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814025-A | Tetrahydrobenzimidazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814051-A | Tetrahydroimidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814054-A | Fused imidazole and pyrazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814045-A | Imidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814052-A | Imidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814055-A | Fused imidazole and pyrazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814046-A | Imidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814061-A | Imidazopyridazine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |