Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.77 |
| ▸ | BTK | Q06187 | 7/20 | 0.71 |
| ▸ | ITK | Q08881 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17936495 | 0.91 | JAK3 (0.69) | EGFRBTK | |
| SCHEMBL9945478 | 0.90 | BTK (0.67) | EGFRBTK | |
| SCHEMBL16513260 | 0.89 | JAK3 (0.77) | EGFRBTK | |
| SCHEMBL28059285 | 0.89 | EGFR (0.67) | EGFRBTKITK | |
| SCHEMBL29537933 | 0.89 | JAK3 (0.77) | EGFRBTK | |
| SCHEMBL24392803 | 0.89 | JAK3 (0.77) | EGFRBTK | |
| SCHEMBL16513364 | 0.88 | EGFR (0.68) | EGFRBTKITK | |
| SCHEMBL9925321 | 0.88 | EGFR (0.68) | EGFRBTK | |
| SCHEMBL16513456 | 0.87 | EGFR (0.67) | EGFRBTKITK | |
| SCHEMBL16513279 | 0.86 | JAK3 (0.66) | EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384695-B | Pyrimidine derivative, preparation method and medical application thereof | 四川海思科制药有限公司 | 2019-12-20 | — | — | CN | disclosed |
| CN-105384695-A | Pyrimidine derivative, preparation method therefor and application thereof in medicine | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |