Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.67 |
| ▸ | BTK | Q06187 | 8/20 | 0.63 |
| ▸ | JAK3 | P52333 | 1/20 | 0.63 |
| ▸ | ITK | Q08881 | 4/20 | 0.62 |
| ▸ | SYK | P43405 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28059266 | 0.89 | EGFR (0.77) | EGFRBTKITK | |
| SCHEMBL4180112 | 0.84 | SYK (0.57) | EGFRBTKJAK3SYK | |
| SCHEMBL17936495 | 0.82 | JAK3 (0.69) | EGFRBTKJAK3 | |
| SCHEMBL28059291 | 0.82 | EGFR (0.64) | EGFRBTKJAK3ITK | |
| SCHEMBL15987129 | 0.81 | TGM2 (0.55) | EGFRBTKITKSYK | |
| SCHEMBL24392803 | 0.81 | JAK3 (0.77) | EGFRBTKJAK3 | |
| SCHEMBL29537933 | 0.81 | JAK3 (0.77) | EGFRBTKJAK3 | |
| SCHEMBL16513260 | 0.81 | JAK3 (0.77) | EGFRBTKJAK3 | |
| SCHEMBL656998 | 0.81 | SYK (0.90) | EGFRBTKITKSYK | |
| SCHEMBL9945478 | 0.80 | BTK (0.67) | EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384695-A | Pyrimidine derivative, preparation method therefor and application thereof in medicine | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |