Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.31 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28275582 | 0.85 | STAT3 (0.46) | STAT3STAT1PDE5AKDM4ENPC1 | |
| SCHEMBL28087191 | 0.85 | STAT3 (0.42) | STAT3STAT1PDE5APDE4APDE4B | |
| SCHEMBL28801306 | 0.85 | STAT3 (0.42) | STAT3STAT1PDE5ATSHR | |
| SCHEMBL28169160 | 0.85 | STAT3 (0.42) | STAT3STAT1PDE5APDE4APDE4B | |
| SCHEMBL28101123 | 0.82 | STAT3 (0.40) | STAT3STAT1 | |
| SCHEMBL825276 | 0.82 | STAT3 (0.43) | STAT3STAT1KDM4ENPC1USP2 | |
| SCHEMBL1945085 | 0.81 | STAT3 (0.49) | STAT3STAT1PDE4APDE4BPDE4C | |
| SCHEMBL226837 | 0.80 | STAT3 (0.59) | STAT3STAT1KDM4ENPC1ALDH1A1 | |
| SCHEMBL31384905 | 0.80 | STAT3 (0.48) | STAT3STAT1PDE4APDE4BPDE4C | |
| SCHEMBL31384871 | 0.80 | STAT3 (0.48) | STAT3STAT1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105597098-B | A kind of bonded gold nanorods compound of Herceptin, preparation method and the application in HER2 positive breast cancer diagnosis and treatment | 哈尔滨医科大学 | 2019-05-31 | — | — | CN | claimed |
| CN-105597098-A | Trastuzumab bond-linking gold nanorod compound, preparation method and application thereof in diagnosis and treatment of HER2 positive breast cancer | UNIV HARBIN MEDICAL | 2016-05-25 | — | — | CN | claimed |
| CN-105597098-B | A kind of bonded gold nanorods compound of Herceptin, preparation method and the application in HER2 positive breast cancer diagnosis and treatment | 哈尔滨医科大学 | 2019-05-31 | — | — | CN | disclosed |
| CN-105597098-A | Trastuzumab bond-linking gold nanorod compound, preparation method and application thereof in diagnosis and treatment of HER2 positive breast cancer | UNIV HARBIN MEDICAL | 2016-05-25 | — | — | CN | disclosed |