Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5711263 | 0.82 | GABRA5 (0.37) | GABRA5GABRB2 | |
| SCHEMBL28324279 | 0.77 | GABRA5 (0.34) | GABRA5GABRB2 | |
| SCHEMBL13278423 | 0.66 | — | — | |
| SCHEMBL10425492 | 0.64 | — | — | |
| SCHEMBL5711305 | 0.64 | GABRA5 (0.56) | GABRA5GABRB2 | |
| SCHEMBL18612449 | 0.60 | — | — | |
| SCHEMBL27886750 | 0.57 | GABRA5 (0.49) | GABRA5GABRB2 | |
| SCHEMBL18612543 | 0.57 | — | — | |
| SCHEMBL18612452 | 0.57 | — | — | |
| SCHEMBL3008261 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109743875-A | The inhibitor of MENIN-MLL interaction | 生命医药公司 | 2019-05-10 | — | — | CN | claimed |
| CN-105745214-B | Tricyclic piperidine compounds | 埃科特莱茵药品有限公司 | 2019-02-19 | — | — | CN | claimed |
| CN-110036015-A | It can be used as the Imidazopyridazine compounds of the regulator of IL-12, IL-23 and/or IFN α response | 百时美施贵宝公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-109743875-A | The inhibitor of MENIN-MLL interaction | 生命医药公司 | 2019-05-10 | — | — | CN | disclosed |
| CN-105745214-B | Tricyclic piperidine compounds | 埃科特莱茵药品有限公司 | 2019-02-19 | — | — | CN | disclosed |
| CN-109071526-A | The acid-addition salts of bridged piperazine derivatives | 阿森纽荣股份公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-108929336-A | Thiazolopyrimidinone class as the active regulator of nmda receptor | 豪夫迈·罗氏有限公司 | 2018-12-04 | — | — | CN | disclosed |
| CN-105612162-B | Thiazolopyrimidinones as modulators of NMDA receptor activity | 豪夫迈·罗氏有限公司 | 2018-08-21 | — | — | CN | disclosed |
| CN-108137588-A | Tricyclic condensed pyridin-2-ones derivative and its purposes as BRD4 inhibitor | 朱比兰特生物系统有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-104254533-B | The pyridinyl compounds of thiazole or thiadiazoles substitution as kinase inhibitor | 百时美施贵宝公司 | 2017-09-08 | — | — | CN | disclosed |
| CN-104169275-B | The pyridine compounds of the triazole substitution as kinase inhibitor | 百时美施贵宝公司 | 2017-06-09 | — | — | CN | disclosed |
| CN-104159896-B | Heterocyclic-substituted pyridyl compounds useful as kinase inhibitors | 百时美施贵宝公司 | 2017-05-24 | — | — | CN | disclosed |
| CN-105612162-A | Thiazolopyrimidinones as modulators of NMDA receptor activity | HOFFMANN LA ROCHE | 2016-05-25 | — | — | CN | disclosed |