Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | FASN | P49327 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TYMP | P19971 | 1/20 | 0.45 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.45 |
| ▸ | GUSB | P08236 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4456699 | 0.77 | FBP1 (0.62) | MAPTFASNKDM4E | |
| SCHEMBL4455323 | 0.76 | MAPT (1.00) | MAPTFASNKDM4E | |
| SCHEMBL31400060 | 0.75 | MAPT (0.48) | MAPTFASNTYMP | |
| SCHEMBL15931645 | 0.75 | FASN (0.57) | MAPTFASNKDM4E | |
| SCHEMBL31400061 | 0.75 | MAPT (0.48) | MAPTFASNTYMP | |
| SCHEMBL21169760 | 0.72 | CDK4 (0.54) | MAPTKDM4E | |
| SCHEMBL6732858 | 0.72 | GUSB (0.37) | MAPTKDM4EGUSB | |
| SCHEMBL6741668 | 0.72 | MAPK1 (0.51) | MAPTGUSB | |
| SCHEMBL8898440 | 0.72 | GRIN2D (0.60) | KDM4E | |
| SCHEMBL8783594 | 0.72 | MAPT (0.68) | MAPTFASNKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105873439-A | Alkyl-linked quinolinyl modulators of ROR γ t | 詹森药业有限公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-105829295-A | Phenyl Linked Quinolinyl Modulators Of Ror-Gamma-T | 詹森药业有限公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-105636952-A | Secondary alcohol quinolinyl modulators of roryt | JANSSEN PHARMACEUTICA NV | 2016-06-01 | — | — | CN | disclosed |