Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKACG | P22612 | 1/20 | 0.41 |
| ▸ | PRKACB | P22694 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 8/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18387 | 1.00 | CSNK1D (0.43) | CSNK1DCSNK1EKCNH2PRKACAPRKACG | |
| SCHEMBL8321907 | 1.00 | CSNK1D (0.43) | CSNK1DCSNK1EKCNH2PRKACAPRKACG | |
| Hydrochloric Acid SCHEMBL28500586 | 0.98 | CSNK1D (0.43) | CSNK1DCSNK1EKCNH2PRKACAPRKACG | |
| Hydrochloric Acid SCHEMBL28214300 | 0.98 | CSNK1D (0.43) | CSNK1DCSNK1EKCNH2PRKACAPRKACG | |
| SCHEMBL2944138 | 0.81 | CHRNA7 (0.47) | PRKACAPRKACGPRKACBPRCPCTSK | |
| SCHEMBL3399522 | 0.81 | PRKACA (0.47) | CSNK1DCSNK1EKCNH2PRKACAPRKACG | |
| SCHEMBL14839620 | 0.81 | PRKACA (0.41) | PRKACAPRKACGPRKACBACVR1CTSK | |
| SCHEMBL22589151 | 0.81 | CHRNA7 (0.47) | PRKACAPRKACGPRKACBPRCPCTSK | |
| SCHEMBL21717791 | 0.81 | MAPT (0.44) | KCNH2PRKACAPRKACGPRKACBACVR1 | |
| SCHEMBL5545595 | 0.81 | MAPT (0.44) | CSNK1DCSNK1EKCNH2PRKACAPRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133994-B2 | Preparation of aprepitant | DR. REDDY'S LABORATORIES LTD. (IN) | 2012-03-13 | — | — | US | disclosed |
| US-20110094321-A1 | PREPARATION OF APREPITANT | DR. REDDY'S LABORATORIES LIMITED (IN) | 2011-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110094321-A1 | PREPARATION OF APREPITANT | KIT, CPA3, CMA1 | CSNK1D 1489/4885CSNK1E 943/4885KCNH2 1289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.