Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.33 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL28227676 | 0.91 | NAPRT (0.39) | NAPRTTSHRTDP1ALDH1A1PLOD2 | |
| Pyridine SCHEMBL28282094 | 0.90 | TSHR (0.53) | NAPRTTSHRTDP1ALDH1A1 | |
| Pyridine SCHEMBL28142784 | 0.88 | NAPRT (0.45) | NAPRTTSHRTDP1ALDH1A1PLOD2 | |
| Pyridine SCHEMBL28163753 | 0.87 | TSHR (0.40) | NAPRTTSHRTDP1ALDH1A1CYP1A2 | |
| Pyridine SCHEMBL28189167 | 0.86 | NAPRT (0.43) | NAPRTTSHRTDP1ALDH1A1PLOD2 | |
| Pyridine SCHEMBL28170475 | 0.86 | NAPRT (0.43) | NAPRTTSHRTDP1ALDH1A1PLOD2 | |
| Pyridine SCHEMBL10977701 | 0.84 | NAPRT (0.60) | NAPRTTSHRTDP1ALDH1A1PLOD2 | |
| Pyridine SCHEMBL20598704 | 0.84 | TSHR (0.60) | NAPRTTSHRTDP1ALDH1A1 | |
| Pyrrole SCHEMBL311019 | 0.84 | — | — | |
| Pyridine SCHEMBL11125163 | 0.84 | NAPRT (0.60) | NAPRTTSHRTDP1ALDH1A1PLOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110269273-A | A kind of preparation method and application of the tobacco humectant based on super-pressure induction | 云南中烟工业有限责任公司 | 2019-09-24 | — | — | CN | disclosed |
| CN-106535886-A | Long-acting polymer delivery system | 赫伦治疗有限公司 | 2017-03-22 | — | — | CN | disclosed |
| CN-102917690-B | Lipid vesicle composition and using method | 麻省理工学院 | 2016-08-24 | — | — | CN | disclosed |