Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 7/20 | 0.76 |
| ▸ | BRAF | P15056 | 4/20 | 0.60 |
| ▸ | ABL1 | P00519 | 7/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18323189 | 0.91 | KIT (0.79) | KITBRAFABL1EGFRFGFR1 | |
| SCHEMBL30080773 | 0.90 | KIT (0.93) | KITBRAFABL1EGFRFGFR1 | |
| SCHEMBL17936186 | 0.90 | KIT (0.93) | KITBRAFABL1EGFRFGFR1 | |
| SCHEMBL24503732 | 0.89 | KIT (0.85) | KITBRAFABL1EGFRFGFR1 | |
| SCHEMBL18323290 | 0.87 | KIT (0.85) | KITBRAFABL1EGFRFGFR1 | |
| SCHEMBL27671596 | 0.87 | KIT (0.68) | KITBRAFABL1EGFRCSF1R | |
| SCHEMBL4103102 | 0.86 | KIT (1.00) | KITBRAFABL1FGFR1KDR | |
| SCHEMBL29856181 | 0.86 | KIT (1.00) | KITBRAFABL1FGFR1KDR | |
| SCHEMBL27754292 | 0.86 | KIT (0.75) | KITBRAFEGFRCSF1R | |
| SCHEMBL24122650 | 0.84 | KIT (0.79) | KITBRAFABL1FGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105837575-B | 3- acetenyl Pyrazolopyrimidine derivative and its preparation method and application | 四川大学 | 2019-01-15 | — | — | CN | disclosed |
| CN-105837575-A | 3-ethynyl pyrazolo pyrimidine derivative and preparation method and application thereof | 四川大学 | 2016-08-10 | — | — | CN | disclosed |